Stéphane Blot

Our objective is to demonstrate in a large animal model of inherited degenerative myopathies the relevance of potential cell therapies for human application. To achieve this aim, we use spontaneous canine myopathies that finely mimick the human situation. The biological effects of promising muscle progenitors (like mesoangioblasts) delivered intra-arterially with routine procedures after specific conditioning (for allogeneic cells with immune suppression or for autologous cells) are demonstrated by multiparametric biomarkers using transposable methods to patients.