Institutions
Stéphane Blot
UPR-Laboratory of neurobiology
Biology and biotherapies of myopathies
Ecole Nationale Vétérinaire d’Alfort
7, avenue du Général de Gaulle
94704 Maisons-Alfort
Tel +331 4396 7171/7047
Fax +331 4396 7089
Our objective is to demonstrate in a large animal model of inherited degenerative myopathies the relevance of potential cell therapies for human application. To achieve this aim, we use spontaneous canine myopathies that finely mimick the human situation. The biological effects of promising muscle progenitors (like mesoangioblasts) delivered intra-arterially with routine procedures after specific conditioning (for allogeneic cells with immune suppression or for autologous cells) are demonstrated by multiparametric biomarkers using transposable methods to patients.