Raphael Scharfmann

The major objective of the team is to define signals regulating functional beta cell mass in rodent and human.

"We are developing and using innovative approaches to better define signals that modulate pancreatic endocrine cell development and function in rodent and human.These studies are performed within national and international consortia (ANR, H2020, EU-IMI, Labex REVIVE). Specifically, we are: Searching for molecules that modulate beta cell development in rodent and Human; Deconstructing-reconstructing human fetal pancreas development; Developing human β cell lines and using them to model diabete; Developing ways to study the role of pancreatic alpha and delta cells in diabetes"