Pierre-Marie Lledo

We are investigating the functional meaning of adult neurogenesis forsensory and cognitive functions. Methodologically, this include morphological, molecular and electrophysiological characterization of new neurons in vitro and in vivo as well as behavioural approaches to investigate the impact of adding new neurons to pre-existing circuits. Special emphases are given to investigate the relative contribution of intrinsic (genetic) and extrinsic (epigenetic) cues regulating this process using genetically manipulated rodents and different environmental paradigms.