Pablo Navarro Gil

We are using mouse Embryonic Stem cells to understand how regulatory networks contribute to cellular decision-making processes in mammalian systems. We aim at understanding (1) the regulatory properties emerging from and the constrains imposed by the modular and dynamic organisation of the network; (2) the epigenetic mechanisms ensuring the rapid reestablishment of the network after each cell division and, conversely, those promoting its dismantling upon differentiation; (3) the contribution of non-coding RNAs to the regulation of the network’s activity.