Laure Bally-Cuif

We aim to understand how neural stem cell populations are maintained at long-term and used for neuro- and gliogenesis in the vertebrate adult brain. We are using the model system zebrafish, where adult neural stem cells are abundant and, in the adult forebrain, directly accessible for intra-vital imaging. We especially focus on Notch3 signaling, which we recently identified as a major positive regulator of NSC quiescence. Overall, we are combining large scale profiling approaches, genetic invalidations, lineage tracing and intra-vital imaging to identify the cellular hierarchies, the cell-cell interactions and the Notch3-interacting cascades that dynamically control the spatio-temporal homeostasis of the forebrain adult neural stem cell pool