Ana Cumano

Stromal cells are non-hematopoietic cells, present in the hematopoietic organs, responsible for the development and maintenance of hematopoietic stem cells (HSC). Our objective is to study of the biological properties of fetal HSC and their stromal environment, to understand stem cell self-renewal. We aim at 1.Prospectively isolate the cellular components of the hematopoietic niche, in murine fetal liver. 2. Identify the environmental and/or cell autonomous signals required for HSC expansion and differentiation.